Apixaban (Eliquis): What it is and why it matters

Apixaban (brand name Eliquis) is a modern oral anticoagulant many doctors choose instead of warfarin. It cuts the risk of stroke in atrial fibrillation and treats or prevents deep vein thrombosis (DVT) and pulmonary embolism (PE). Because it works quickly and doesn’t need routine INR checks, lots of patients find it easier to use—but it still needs respect. Know what to watch for, how to take it, and when to call your clinician.

How apixaban is usually taken

Standard adult dosing depends on the reason you’re taking it. For stroke prevention in non-valvular atrial fibrillation the common dose is 5 mg twice daily; some people take 2.5 mg twice daily if they’re older, lighter, or have reduced kidney function. For DVT/PE treatment it often starts with 10 mg twice daily for 7 days, then 5 mg twice daily. Always follow your doctor’s instructions—don’t adjust dose on your own.

Take apixaban with or without food at the same times each day. If you miss a dose, take it as soon as you remember that day. Don’t take two doses to make up for a missed one. Stopping suddenly raises the risk of clots, so talk to your prescriber before stopping for any reason.

Safety, side effects, and interactions

The main risk is bleeding. Watch for heavy bruising, nosebleeds that won’t stop, pink or dark urine, black stools, coughing or vomiting blood, or severe headaches or weakness. If you have sudden severe bleeding or signs of a stroke, go to the ER immediately.

Apixaban interacts with other drugs that affect bleeding (aspirin, NSAIDs, other blood thinners) and with some strong enzyme inhibitors or inducers (for example, certain antifungals, HIV meds, and some seizure drugs). Tell every clinician and pharmacist you take apixaban before they prescribe or give you anything new.

Kidney and liver health matter. Your provider will check kidney function before starting and may monitor it periodically. Unlike warfarin, routine blood clotting tests like INR aren’t useful for apixaban.

If you need urgent reversal for major bleeding or emergency surgery, there’s a specific antidote (andexanet alfa) in many hospitals. If that’s not available, doctors can use prothrombin complex concentrates (PCC) and supportive care.

Planning surgery? Your surgeon or cardiologist will tell you when to stop apixaban before the procedure—often 24–48 hours depending on bleeding risk and kidney function. Don’t stop on your own unless instructed.

Finally, buy medications only from licensed pharmacies and keep a current list of meds and allergies in your wallet. If you’re ever unsure about dosing, interactions, or bleeding risk, call your prescriber. Apixaban is powerful and convenient when used correctly—stay informed and stay safe.